Scientists have discovered that a parasite found in cat litter, Toxoplasma gondii, could potentially treat neurological conditions like Alzheimer’s and Parkinson’s. This parasite, often present in feline feces, has been engineered to deliver therapeutic proteins across the blood-brain barrier directly to neurons in mice. This breakthrough, led by researchers from the University of Glasgow and Tel Aviv University, could revolutionize the delivery of treatments for cognitive disorders.
Toxoplasma gondii is known for its ability to remain dormant in humans, with about a third of the global population carrying it. Its natural capacity to cross protective barriers in the body and reach the brain makes it an ideal candidate for delivering medications directly to affected areas. This method could bypass previous challenges in treating brain disorders, where reaching the correct neuronal location has been a significant hurdle.
The study focuses on the MeCP2 protein, targeted for its potential in treating Rett syndrome, a severe neurological disorder. The engineered parasites successfully produced and delivered this protein to brain cells in laboratory settings. Future research will aim to modify the parasites to ensure they are safe by making them die after delivering their payload.
Published in Nature Microbiology, this innovative approach is still in its early stages and requires further research to improve efficiency and safety. Despite the promise shown, the inherent risks of Toxoplasma infection necessitate careful consideration and extensive testing before this method can be applied clinically.
